Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Bradshaw, Angela C., Coughlan, Lynda, Miller, Ashley M., Alba, Raul, van Rooijen, Nico, Nicklin, Stuart A., Baker, Andrew H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier Science Publishers 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520007/
https://ncbi.nlm.nih.gov/pubmed/22626939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.05.025
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