Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X

Human adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown. Upon contact with blood, vectors based on adenovirus serotype 5 (Ad5) binds to FX via the hexon protein with nanomolar affinity, leading to selec...

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Главные авторы: Bradshaw, Angela C., Parker, Alan L., Duffy, Margaret R., Coughlan, Lynda, van Rooijen, Nico, Kähäri, Veli-Matti, Nicklin, Stuart A., Baker, Andrew H.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951380/
https://ncbi.nlm.nih.gov/pubmed/20949078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001142
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