Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck

BACKGROUND: Only a minority of cancer patients benefits from the combination of EGFR-inhibition and radiotherapy in head and neck squamous cell carcinoma (HNSCC). A potential resistance mechanism is activation of EGFR and/or downstream pathways by stimuli in the microenvironment. The aim of this stu...

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Autores principales: Stegeman, Hanneke, Kaanders, Johannes H, Wheeler, Deric L, van der Kogel, Albert J, Verheijen, Marieke M, Waaijer, Stijn J, Iida, Mari, Grénman, Reidar, Span, Paul N, Bussink, Johan
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517352/
https://ncbi.nlm.nih.gov/pubmed/23046567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-463
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