Proteomics Analysis of Brain Proteins in APP/PS-1 Human Double Mutant Knock-in Mice with Increasing Amyloid β-Peptide Deposition: Insights into the Effects of in vivo Treatment with N-Acetylcysteine as a Potential Therapeutic Intervention in Mild Cognitive Impairment and Alzheimer Disease

Proteomics analyses were performed on the brains of wild-type (WT) controls and an Alzheimer’s disease (AD) mouse model, APP/PS-1 human double mutant knock in mice. Mice were given either drinking water or water supplemented with N-acetylcysteine (NAC) (2mg/kg body weight) for a period of five month...

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Detalhes bibliográficos
Main Authors: Robinson, Renã A. S., Joshi, Gururaj, Huang, Quanzhen, Sultana, Rukhsana, Baker, Austin S., Cai, Jian, Pierce, William, St. Clair, Daret K., Markesbery, William R., Butterfield, D. Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517055/
https://ncbi.nlm.nih.gov/pubmed/21954051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201000523
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