Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double knock-in mice: Relevance to Alzheimer disease

Using APP(NLh)/APP(NLh)×PS-1(P246L)/PS-1(P246L) human double knock-in (APP/PS-1) mice, we examined whether phosphatidylserine (PtdSer) asymmetry is significantly altered in brain of this familial Alzheimer disease mouse model in an age-dependent manner as a result of oxidative stress, toxic Aβ(1–42)...

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Main Authors: Bader Lange, Miranda L., Clair, Daret St., Markesbery, William R., Studzinski, Christa M., Murphy, M. Paul, Butterfield, D. Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834848/
https://ncbi.nlm.nih.gov/pubmed/20083199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.01.004
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