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Proteomics Identification of Specifically Carbonylated Brain Proteins in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) Human Double Mutant Knock-in Mice Model of Alzheimer Disease as a Function of Age
Alzheimer disease (AD) is the most common type of dementia and is characterized pathologically by the presence of neurofibrillary tangles (NFTs), senile plaques (SPs), and loss of synapses. The main component of SP is amyloid-beta peptide (Aβ), a 39 to 43 amino acid peptide, generated by the proteol...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199338/ https://ncbi.nlm.nih.gov/pubmed/21726674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2011.06.015 |
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