Proteomics Identification of Specifically Carbonylated Brain Proteins in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) Human Double Mutant Knock-in Mice Model of Alzheimer Disease as a Function of Age

Alzheimer disease (AD) is the most common type of dementia and is characterized pathologically by the presence of neurofibrillary tangles (NFTs), senile plaques (SPs), and loss of synapses. The main component of SP is amyloid-beta peptide (Aβ), a 39 to 43 amino acid peptide, generated by the proteol...

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Main Authors: Sultana, Rukhsana, Robinson, Renã A. S., Di Domenico, Fabio, Mohmmad Abdul, Hafiz, St. Clair, Daret K., Markesbery, William R., Cai, Jian, Pierce, William M., Butterfield, D. Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199338/
https://ncbi.nlm.nih.gov/pubmed/21726674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2011.06.015
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