β-Amyloid Mediated Nitration of Manganese Superoxide Dismutase : Implication for Oxidative Stress in a APP(NLh/NLh) X PS-1(P264L/P264L) Double Knock-In Mouse Model of Alzheimer’s Disease

Alzheimer’s disease is a multifactorial, progressive, age-related neurodegenerative disease. In familial Alzheimer’s disease, Aβ is excessively produced and deposited because of mutations in the amyloid precursor protein, presenilin-1, and presenilin-2 genes. Here, we generated a double homozygous k...

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Detalhes bibliográficos
Main Authors: Anantharaman, Muthuswamy, Tangpong, Jitbanjong, Keller, Jeffery N., Murphy, Michael P., Markesbery, William R., Kiningham, Kelley K., St. Clair, Daret K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606606/
https://ncbi.nlm.nih.gov/pubmed/16651627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051223
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