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Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere
The TRF2-Rap1 complex suppresses non-homologous end joining and interacts with DNAPK-C to prevent end joining. We previously demonstrated that hTRF2 is a double strand telomere binding protein that forms t-loops in vitro and recognizes three- and four-way junctions independent of DNA sequence. How t...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3516710/ https://ncbi.nlm.nih.gov/pubmed/23086976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415984 |
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