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Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere

The TRF2-Rap1 complex suppresses non-homologous end joining and interacts with DNAPK-C to prevent end joining. We previously demonstrated that hTRF2 is a double strand telomere binding protein that forms t-loops in vitro and recognizes three- and four-way junctions independent of DNA sequence. How t...

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Autores principales: Arat, N. Özlem, Griffith, Jack D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516710/
https://ncbi.nlm.nih.gov/pubmed/23086976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415984
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