Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >90% of cancers. However, any direct causal link between...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Sharma, Shalu, Mukherjee, Ananda Kishore, Roy, Shuvra Shekhar, Bagri, Sulochana, Lier, Silje, Verma, Meenakshi, Sengupta, Antara, Kumar, Manish, Nesse, Gaute, Prakash, Deo Pandey, Chowdhury, Shantanu
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611063/
https://ncbi.nlm.nih.gov/pubmed/34010660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109154
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