Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >90% of cancers. However, any direct causal link between...

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Vydáno v:Cell Rep
Hlavní autoři: Sharma, Shalu, Mukherjee, Ananda Kishore, Roy, Shuvra Shekhar, Bagri, Sulochana, Lier, Silje, Verma, Meenakshi, Sengupta, Antara, Kumar, Manish, Nesse, Gaute, Prakash, Deo Pandey, Chowdhury, Shantanu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611063/
https://ncbi.nlm.nih.gov/pubmed/34010660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109154
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