Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >90% of cancers. However, any direct causal link between...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Sharma, Shalu, Mukherjee, Ananda Kishore, Roy, Shuvra Shekhar, Bagri, Sulochana, Lier, Silje, Verma, Meenakshi, Sengupta, Antara, Kumar, Manish, Nesse, Gaute, Prakash, Deo Pandey, Chowdhury, Shantanu
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611063/
https://ncbi.nlm.nih.gov/pubmed/34010660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109154
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