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INCREASED CELL GROWTH DUE TO A NEW LIPASE-GEF (PHOSPHOLIPASE D2) FASTLY ACTING ON RAS
We report the novel finding that Phospholipase D2 (PLD2), through its PX and PH domains, binds specifically to Ras and catalyzes the GDP/GTP exchange (i.e., is a GEF), with potency comparable to Ras-GEF-1, a known Ras-GEF. Cells overexpressing PLD2-GEF inactive mutants (F129Y and R172C/L173A) fail t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3508343/ https://ncbi.nlm.nih.gov/pubmed/22960035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.08.010 |
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