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Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2)

PLD2 plays a key role in cell membrane lipid reorganization and as a key cell signaling protein in leukocyte chemotaxis and phagocytosis. Adding to the large role for a lipase in cellular functions, recently, our lab has identified a PLD2-Rac2 binding through two CRIB domains in PLD2 and has defined...

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Autor principal: Gomez-Cambronero, Julian
Format: Artigo
Idioma:Inglês
Publicat: Society for Leukocyte Biology 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427609/
https://ncbi.nlm.nih.gov/pubmed/22750546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0212073
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