The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells

Activation of adaptive mechanisms plays a crucial role in cancer progression and drug resistance by allowing cell survival under stressful conditions. Therefore, inhibition of the adaptive response is considered as a prospective therapeutic strategy. The PERK-eIF2α phosphorylation pathway is an impo...

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Main Authors: Kusio-Kobialka, Monika, Podszywalow-Bartnicka, Paulina, Peidis, Philippos, Glodkowska-Mrowka, Eliza, Wolanin, Kamila, Leszak, Grzegorz, Seferynska, Ilona, Stoklosa, Tomasz, Koromilas, Antonis E., Piwocka, Katarzyna
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507502/
https://ncbi.nlm.nih.gov/pubmed/23095523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22387
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