Monoubiquitinated Fanconi Anemia D2 (FANCD2-Ub) Is Required for BCR-ABL1 Kinase -Induced Leukemogenesis

Fanconi D2 (FANCD2) is monoubiquitinated on K561 (FANCD2-Ub) in response to DNA double-strand breaks (DSBs) to stimulate repair of these potentially lethal DNA lesions. FANCD2-Ub was upregulated in CD34+ chronic myeloid leukemia (CML) cells and in BCR-ABL1 kinase –positive cell lines in response to...

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Main Authors: Koptyra, Mateusz, Stoklosa, Tomasz, Hoser, Grazyna, Glodkowska-Mrowka, Eliza, Seferynska, Ilona, Klejman, Agata, Blasiak, Janusz, Skorski, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145022/
https://ncbi.nlm.nih.gov/pubmed/21519342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.91
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