BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

Mutations in the BCR/ABL kinase domain play a major role in resistance to imatinib mesylate (IM). We report here that BCR/ABL kinase stimulates reactive oxygen species (ROS), which causes oxidative DNA damage, resulting in mutations in the kinase domain. The majority of mutations involved A/T→G/C an...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Koptyra, Mateusz, Falinski, Rafal, Nowicki, Michal O., Stoklosa, Tomasz, Majsterek, Ireneusz, Nieborowska-Skorska, Margaret, Blasiak, Janusz, Skorski, Tomasz
Format: Artigo
Langue:Inglês
Publié: The American Society of Hematology 2006
Sujets:
Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895841/
https://ncbi.nlm.nih.gov/pubmed/16527898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-07-2815
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires