BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

Mutations in the BCR/ABL kinase domain play a major role in resistance to imatinib mesylate (IM). We report here that BCR/ABL kinase stimulates reactive oxygen species (ROS), which causes oxidative DNA damage, resulting in mutations in the kinase domain. The majority of mutations involved A/T→G/C an...

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Autori principali: Koptyra, Mateusz, Falinski, Rafal, Nowicki, Michal O., Stoklosa, Tomasz, Majsterek, Ireneusz, Nieborowska-Skorska, Margaret, Blasiak, Janusz, Skorski, Tomasz
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2006
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895841/
https://ncbi.nlm.nih.gov/pubmed/16527898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-07-2815
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