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BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells
The oncogenic BCR/ABL tyrosine kinase facilitates the repair of DNA double-strand breaks (DSBs). We find that after γ-irradiation BCR/ABL-positive leukemia cells accumulate more DSBs in comparison to normal cells. These lesions are efficiently repaired in a time-dependent fashion by BCR/ABL-stimulat...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856314/ https://ncbi.nlm.nih.gov/pubmed/16297667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2005.10.005 |
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