Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions

Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA alkylation damage by flagging O(6)-alkylguanine lesions for nucleotide excision repair (NER). We show that both ATL proteins bind with high affinity...

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Detalhes bibliográficos
Main Authors: Wilkinson, Oliver J., Latypov, Vitaly, Tubbs, Julie L., Millington, Christopher L., Morita, Rihito, Blackburn, Hannah, Marriott, Andrew, McGown, Gail, Thorncroft, Mary, Watson, Amanda J., Connolly, Bernard A., Grasby, Jane A., Masui, Ryoji, Hunter, Christopher A., Tainer, John A., Margison, Geoffrey P., Williams, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503161/
https://ncbi.nlm.nih.gov/pubmed/23112169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209451109
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