Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions

Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA alkylation damage by flagging O(6)-alkylguanine lesions for nucleotide excision repair (NER). We show that both ATL proteins bind with high affinity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wilkinson, Oliver J., Latypov, Vitaly, Tubbs, Julie L., Millington, Christopher L., Morita, Rihito, Blackburn, Hannah, Marriott, Andrew, McGown, Gail, Thorncroft, Mary, Watson, Amanda J., Connolly, Bernard A., Grasby, Jane A., Masui, Ryoji, Hunter, Christopher A., Tainer, John A., Margison, Geoffrey P., Williams, David M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503161/
https://ncbi.nlm.nih.gov/pubmed/23112169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209451109
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