Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation–π interactions

Alkyltransferase-like (ATL) proteins in Schizosaccharomyces pombe (Atl1) and Thermus thermophilus (TTHA1564) protect against the adverse effects of DNA alkylation damage by flagging O(6)-alkylguanine lesions for nucleotide excision repair (NER). We show that both ATL proteins bind with high affinity...

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Bibliografiske detaljer
Main Authors: Wilkinson, Oliver J., Latypov, Vitaly, Tubbs, Julie L., Millington, Christopher L., Morita, Rihito, Blackburn, Hannah, Marriott, Andrew, McGown, Gail, Thorncroft, Mary, Watson, Amanda J., Connolly, Bernard A., Grasby, Jane A., Masui, Ryoji, Hunter, Christopher A., Tainer, John A., Margison, Geoffrey P., Williams, David M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503161/
https://ncbi.nlm.nih.gov/pubmed/23112169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209451109
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