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DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O(6)-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy
O(6)-alkylguanine-DNA alkyltransferase (AGT) is a crucial target both for the prevention of cancer and for chemotherapy, since it repairs mutagenic lesions in DNA, and it limits the effectiveness of alkylating chemotherapies. AGT catalyzes the unique, single-step, direct damage reversal repair of O(...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1993358/ https://ncbi.nlm.nih.gov/pubmed/17485252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.03.011 |
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