Structural Basis of O(6)-Alkylguanine Recognition by a Bacterial Alkyltransferase-like DNA Repair Protein

Alkyltransferase-like proteins (ATLs) are a novel class of DNA repair proteins related to O(6)-alkylguanine-DNA alkyltransferases (AGTs) that tightly bind alkylated DNA and shunt the damaged DNA into the nucleotide excision repair pathway. Here, we present the first structure of a bacterial ATL, fro...

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Hlavní autoři: Aramini, James M., Tubbs, Julie L., Kanugula, Sreenivas, Rossi, Paolo, Ertekin, Asli, Maglaqui, Melissa, Hamilton, Keith, Ciccosanti, Colleen T., Jiang, Mei, Xiao, Rong, Soong, Ta-Tsen, Rost, Burkhard, Acton, Thomas B., Everett, John K., Pegg, Anthony E., Tainer, John A., Montelione, Gaetano T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859536/
https://ncbi.nlm.nih.gov/pubmed/20212037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093591
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