Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus

The thymus generates T cells with diverse specificities and functions. To assess the contribution of cytokine receptors to the differentiation of T cell subsets in the thymus, we constructed conditional knockout mice in which IL-7Rα or common cytokine receptor γ chain (γ(c)) genes were deleted in th...

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Main Authors: McCaughtry, Tom M., Etzensperger, Ruth, Alag, Amala, Tai, Xuguang, Kurtulus, Sema, Park, Jung-Hyun, Grinberg, Alex, Love, Paul, Feigenbaum, Lionel, Erman, Batu, Singer, Alfred
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501363/
https://ncbi.nlm.nih.gov/pubmed/23109710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121505
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