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Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca(2+)/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation
InsP(3)-mediated calcium release through the type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) in cardiac myocytes results in the activation of associated CaMKII, thus enabling the kinase to act on downstream targets, such as histone deacetylases 4 and 5 (HDAC4 and HDAC5). The CaMKII activity...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501088/ https://ncbi.nlm.nih.gov/pubmed/23019322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374058 |
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