Structural Insights into Ca(2+)-dependent Regulation of Inositol 1,4,5-Trisphosphate Receptors by CaBP1

Calcium-binding protein 1 (CaBP1), a neuron-specific member of the calmodulin (CaM) superfamily, modulates Ca(2+)-dependent activity of inositol 1,4,5-trisphosphate receptors (InsP(3)Rs). Here we present NMR structures of CaBP1 in both Mg(2+)-bound and Ca(2+)-bound states and their structural intera...

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Detalhes bibliográficos
Main Authors: Li, Congmin, Chan, Jenny, Haeseleer, Franciose, Mikoshiba, Katsuhiko, Palczewski, Krzysztof, Ikura, Mitsuhiko, Ames, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629100/
https://ncbi.nlm.nih.gov/pubmed/19008222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806513200
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