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Structural Insights into Activation of the Retinal L-type Ca(2+) Channel (Cav1.4) by Ca(2+)-binding Protein 4 (CaBP4)
CaBP4 modulates Ca(2+)-dependent activity of L-type voltage-gated Ca(2+) channels (Cav1.4) in retinal photoreceptor cells. Mg(2+) binds to the first and third EF-hands (EF1 and EF3), and Ca(2+) binds to EF1, EF3, and EF4 of CaBP4. Here we present NMR structures of CaBP4 in both Mg(2+)-bound and Ca(2...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4223327/ https://ncbi.nlm.nih.gov/pubmed/25258313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604439 |
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