Calcineurin-NFATc Regulates Type 2 Inositol 1,4,5-Trisphosphate Receptor (InsP(3)R2) Expression during Cardiac Remodeling

In heart, the type 2 inositol 1,4,5-triphosphate receptor (InsP(3)R2) is the predominant isoform expressed and is localized in the nuclear membrane of ventricular myocytes. InsP(3)R2-mediated Ca(2+) release regulates hypertrophy specific gene expression by modulating CaMKIIδ, histone deacetylase, an...

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Hauptverfasser: Sankar, Natesan, deTombe, Pieter P., Mignery, Gregory A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937684/
https://ncbi.nlm.nih.gov/pubmed/24415751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495242
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