The Type 2 Inositol (1,4,5)-Trisphosphate (InsP(3)) Receptor Determines the Sensitivity of InsP(3)-induced Ca(2+) Release to ATP in Pancreatic Acinar Cells

Calcium release through inositol (1,4,5)-trisphosphate receptors (InsP(3)R) is the primary signal driving digestive enzyme and fluid secretion from pancreatic acinar cells. The type 2 (InsP(3)R2) and type 3 (InsP(3)R3) InsP(3)R are the predominant isoforms expressed in acinar cells and are required...

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Библиографические подробности
Главные авторы: Park, Hyung Seo, Betzenhauser, Matthew J., Won, Jong Hak, Chen, Ju, Yule, David I.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
Предметы:
Mechanisms of Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533790/
https://ncbi.nlm.nih.gov/pubmed/18658132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804184200
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