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Modulation of Inositol 1,4,5-Trisphosphate Receptor Type 2 Channel Activity by Ca(2+)/Calmodulin-dependent Protein Kinase II (CaMKII)-mediated Phosphorylation

InsP(3)-mediated calcium release through the type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) in cardiac myocytes results in the activation of associated CaMKII, thus enabling the kinase to act on downstream targets, such as histone deacetylases 4 and 5 (HDAC4 and HDAC5). The CaMKII activity...

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Sonraí Bibleagrafaíochta
Main Authors: Maxwell, Joshua T., Natesan, Sankar, Mignery, Gregory A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501088/
https://ncbi.nlm.nih.gov/pubmed/23019322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374058
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