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Inhibitory Phosphorylation of GSK-3 by CaMKII Couples Depolarization to Neuronal Survival

Glycogen synthase kinase-3 (GSK-3) plays a critical role in neuronal apoptosis. The two mammalian isoforms of the kinase, GSK-3α and GSK-3β, are inhibited by phosphorylation at Ser-21 and Ser-9, respectively. Depolarization, which is vital for neuronal survival, causes both an increase in Ser-21/9 p...

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Detalhes bibliográficos
Main Authors: Song, Bin, Lai, Bingquan, Zheng, Zhihao, Zhang, Yuying, Luo, Jingyan, Wang, Chong, Chen, Yuan, Woodgett, James R., Li, Mingtao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003410/
https://ncbi.nlm.nih.gov/pubmed/20841359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.130351
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