Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter

The serotonin transporter (SERT) controls synaptic serotonin levels and is the primary target for antidepressants, including selective serotonin reuptake inhibitors (e.g. (S)-citalopram) and tricyclic antidepressants (e.g. clomipramine). In addition to a high affinity binding site, SERT possesses a...

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Bibliografiske detaljer
Main Authors: Plenge, Per, Shi, Lei, Beuming, Thijs, Te, Jerez, Newman, Amy Hauck, Weinstein, Harel, Gether, Ulrik, Loland, Claus J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501018/
https://ncbi.nlm.nih.gov/pubmed/23007398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371765
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