Structure–activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding

The pentameric B subunit of the type II heat-labile enterotoxin of Escherichia coli (LT-IIb-B(5)) is a potent signaling molecule capable of modulating innate immune responses. It has previously been shown that LT-IIb-B(5), but not the LT-IIb-­B(5) Ser74Asp variant [LT-IIb-B(5)(S74D)], activates Toll...

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Detalhes bibliográficos
Main Authors: Cody, Vivian, Pace, Jim, Nawar, Hesham F., King-Lyons, Natalie, Liang, Shuang, Connell, Terry D., Hajishengallis, George
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498930/
https://ncbi.nlm.nih.gov/pubmed/23151625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444912038917
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