In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B(5)) from Escherichia coli

The pentameric B subunit of the Escherichia coli LT-IIb enterotoxin (LT-IIb-B(5)) activates TLR2 signaling in macrophages. Herein we demonstrate that LT-IIb-B(5), in contrast to a TLR2-nonbinding point mutant, induces functional activation of bone marrow-derived dendritic cells and stimulates CD4(+)...

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Main Authors: Liang, Shuang, Hosur, Kavita B., Nawar, Hesham F., Russell, Michael W., Connell, Terry D., Hajishengallis, George
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700856/
https://ncbi.nlm.nih.gov/pubmed/19450646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.05.027
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