Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I)

LT-IIb, a type II heat-labile enterotoxin of Escherichia coli, is a potent immunologic adjuvant with high affinity binding for ganglioside GD1a. Earlier study suggested that LT-IIb bound preferentially to the terminal sugar sequence NeuAcα2-3Galβ1-3GalNAc. However, studies in our laboratory suggeste...

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Detalhes bibliográficos
Main Authors: Berenson, Charles S, Nawar, Hesham F, Yohe, Herbert C, Castle, Sherry A, Ashline, David J, Reinhold, Vernon N, Hajishengallis, George, Connell, Terry D
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782182/
https://ncbi.nlm.nih.gov/pubmed/19749203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwp141
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