Binding to Gangliosides Containing N-Acetylneuraminic Acid Is Sufficient To Mediate the Immunomodulatory Properties of the Nontoxic Mucosal Adjuvant LT-IIb(T13I)

By use of a mouse mucosal immunization model, LT-IIb(T13I), a nontoxic mutant type II heat-labile enterotoxin, was shown to have potent mucosal and systemic adjuvant properties. In contrast to LT-IIb, which binds strongly to ganglioside receptors decorated with either N-acetylneuraminic acid (NeuAc)...

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Detalhes bibliográficos
Main Authors: Nawar, Hesham F., Berenson, Charles S., Hajishengallis, George, Takematsu, Hiromu, Mandell, Lorrie, Clare, Ragina L., Connell, Terry D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccine Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884423/
https://ncbi.nlm.nih.gov/pubmed/20392887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00076-10
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