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Crystallization and preliminary X-ray diffraction analysis of two peptides from Alzheimer PHF in complex with the MN423 antibody Fab fragment

The major constituent of the Alzheimer’s disease paired helical filaments (PHF) core is the intrinsically disordered protein (IDP) tau. Globular binding partners, e.g. monoclonal antibodies, can stabilize the fold of disordered tau in complexes. A previously published structure of a proteolytically...

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Autori principali: Skrabana, Rostislav, Cehlar, Ondrej, Flachbartova, Zuzana, Kovac, Andrej, Sevcik, Jozef, Novak, Michal
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497976/
https://ncbi.nlm.nih.gov/pubmed/23027744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112033477
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