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Crystallization and preliminary X-ray diffraction analysis of tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments

The Alzheimer’s disease-associated protein tau is an intrinsically disordered protein with no preferred structure in solution. Under physiological conditions, tau binds to microtubules and regulates their dynamics, whereas during the development of neurodegeneration tau dissociates from microtubules...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cehlar, Ondrej, Skrabana, Rostislav, Kovac, Andrej, Kovacech, Branislav, Novak, Michal
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497975/
https://ncbi.nlm.nih.gov/pubmed/23027743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112030382
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