Crystallization and preliminary X-ray diffraction analysis of tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments

The Alzheimer’s disease-associated protein tau is an intrinsically disordered protein with no preferred structure in solution. Under physiological conditions, tau binds to microtubules and regulates their dynamics, whereas during the development of neurodegeneration tau dissociates from microtubules...

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Bibliographic Details
Main Authors: Cehlar, Ondrej, Skrabana, Rostislav, Kovac, Andrej, Kovacech, Branislav, Novak, Michal
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2012
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497975/
https://ncbi.nlm.nih.gov/pubmed/23027743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112030382
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