Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation

Immunotherapies targeting pathological tau have recently emerged as a promising approach for treatment of neurodegenerative disorders. We have previously showed that the mouse antibody DC8E8 discriminates between healthy and pathological tau, reduces tau pathology in murine tauopathy models and inhi...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol Commun
Autors principals: Zilkova, Monika, Nolle, Anna, Kovacech, Branislav, Kontsekova, Eva, Weisova, Petronela, Filipcik, Peter, Skrabana, Rostislav, Prcina, Michal, Hromadka, Tomas, Cehlar, Ondrej, Rolkova, Gabriela Paulikova, Maderova, Denisa, Novak, Michal, Zilka, Norbert, Hoozemans, Jeroen J. M.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7257136/
https://ncbi.nlm.nih.gov/pubmed/32471486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00948-z
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