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Crystallization and preliminary X-ray diffraction analysis of two peptides from Alzheimer PHF in complex with the MN423 antibody Fab fragment

The major constituent of the Alzheimer’s disease paired helical filaments (PHF) core is the intrinsically disordered protein (IDP) tau. Globular binding partners, e.g. monoclonal antibodies, can stabilize the fold of disordered tau in complexes. A previously published structure of a proteolytically...

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Bibliographische Detailangaben
Hauptverfasser: Skrabana, Rostislav, Cehlar, Ondrej, Flachbartova, Zuzana, Kovac, Andrej, Sevcik, Jozef, Novak, Michal
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497976/
https://ncbi.nlm.nih.gov/pubmed/23027744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112033477
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