Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362

Interleukin-3 (IL-3) is a member of the beta common family of cytokines that regulate multiple functions of myeloid cells. The IL-3 receptor-specific alpha subunit (IL3Rα) is overexpressed on stem cells/progenitor cells of patients with acute myeloid leukaemia, where elevated receptor expression cor...

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Autors principals: Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Dhagat, Urmi, Owczarek, Catherine M., Hardy, Matthew P., Fabri, Louis J., Scotney, Pierre D., Nash, Andrew D., Wilson, Nicholas J., Lopez, Angel F., Parker, Michael W.
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2014
Matèries:
Crystallization Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944702/
https://ncbi.nlm.nih.gov/pubmed/24598927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14002593
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