Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Aβ peptides associated with Alzheimer’s disease

The murine monoclonal antibody WO2 specifically binds the N-terminal region of the amyloid β peptide (Aβ) associated with Alzheimer’s disease. This region of Aβ has been shown to be the immunodominant B-cell epitope of the peptide and hence is considered to be a basis for the development of immunoth...

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Detalhes bibliográficos
Main Authors: Wun, Kwok S., Miles, Luke A., Crespi, Gabriela A. N., Wycherley, Kaye, Ascher, David B., Barnham, Kevin J., Cappai, Roberto, Beyreuther, Konrad, Masters, Colin L., Parker, Michael W., McKinstry, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2008
Assuntos:
Crystallization Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376392/
https://ncbi.nlm.nih.gov/pubmed/18453721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108011718
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