Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody

Prion diseases are neurodegenerative diseases that are characterized by the con­version of the cellular prion protein PrP(c) to the pathogenic isoform PrP(sc). Several antibodies are known to interact with the cellular prion protein and to inhibit this transition. An antibody Fab fragment, Fab POM1,...

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Bibliografiska uppgifter
Huvudupphovsmän: Baral, Pravas Kumar, Wieland, Barbara, Swayampakula, Mridula, Polymenidou, Magdalini, Aguzzi, Adriano, Kav, Nat N. V., James, Michael N. G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: International Union of Crystallography 2011
Ämnen:
Crystallization Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212364/
https://ncbi.nlm.nih.gov/pubmed/22102029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111026273
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