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Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody

Prion diseases are neurodegenerative diseases that are characterized by the con­version of the cellular prion protein PrP(c) to the pathogenic isoform PrP(sc). Several antibodies are known to interact with the cellular prion protein and to inhibit this transition. An antibody Fab fragment, Fab POM1,...

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Main Authors: Baral, Pravas Kumar, Wieland, Barbara, Swayampakula, Mridula, Polymenidou, Magdalini, Aguzzi, Adriano, Kav, Nat N. V., James, Michael N. G.
格式: Artigo
語言:Inglês
出版: International Union of Crystallography 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212364/
https://ncbi.nlm.nih.gov/pubmed/22102029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111026273
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