Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Aβ peptides associated with Alzheimer’s disease

The murine monoclonal antibody WO2 specifically binds the N-terminal region of the amyloid β peptide (Aβ) associated with Alzheimer’s disease. This region of Aβ has been shown to be the immunodominant B-cell epitope of the peptide and hence is considered to be a basis for the development of immunoth...

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Autores principales: Wun, Kwok S., Miles, Luke A., Crespi, Gabriela A. N., Wycherley, Kaye, Ascher, David B., Barnham, Kevin J., Cappai, Roberto, Beyreuther, Konrad, Masters, Colin L., Parker, Michael W., McKinstry, William J.
Formato: Artigo
Lenguaje:Inglês
Publicado: International Union of Crystallography 2008
Materias:
Crystallization Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376392/
https://ncbi.nlm.nih.gov/pubmed/18453721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108011718
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