Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator

Channel activators (potentiators) of cystic fibrosis (CF) transmembrane conductance regulator (CFTR), can be used for the treatment of the small subset of CF patients that carry plasma membrane-resident CFTR mutants. However, approximately 90% of CF patients carry the misfolded ΔF508-CFTR and are po...

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Bibliographic Details
Main Authors: Luciani, Alessandro, Villella, Valeria Rachela, Esposito, Speranza, Gavina, Manuela, Russo, Ilaria, Silano, Marco, Guido, Stefano, Pettoello-Mantovani, Massimo, Carnuccio, Rosa, Scholte, Bob, De Matteis, Antonella, Maiuri, Maria Chiara, Raia, Valeria, Luini, Alberto, Kroemer, Guido, Maiuri, Luigi
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
Subjects:
Translational Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494594/
https://ncbi.nlm.nih.gov/pubmed/22874563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.21483
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