Targeting autophagy as a novel strategy for facilitating the therapeutic action of potentiators on ΔF508 cystic fibrosis transmembrane conductance regulator

Channel activators (potentiators) of cystic fibrosis (CF) transmembrane conductance regulator (CFTR), can be used for the treatment of the small subset of CF patients that carry plasma membrane-resident CFTR mutants. However, approximately 90% of CF patients carry the misfolded ΔF508-CFTR and are po...

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Main Authors: Luciani, Alessandro, Villella, Valeria Rachela, Esposito, Speranza, Gavina, Manuela, Russo, Ilaria, Silano, Marco, Guido, Stefano, Pettoello-Mantovani, Massimo, Carnuccio, Rosa, Scholte, Bob, De Matteis, Antonella, Maiuri, Maria Chiara, Raia, Valeria, Luini, Alberto, Kroemer, Guido, Maiuri, Luigi
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
Assuntos:
Translational Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494594/
https://ncbi.nlm.nih.gov/pubmed/22874563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.21483
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