Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism. We recently showed that presenilin-1 and -2, the catalytic components of γ-secretase, and γ-secretase activity itself, are highly enriched in a subcompartmen...

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Bibliografische gegevens
Hoofdauteurs: Area-Gomez, Estela, del Carmen Lara Castillo, Maria, Tambini, Marc D, Guardia-Laguarta, Cristina, de Groof, Ad J C, Madra, Moneek, Ikenouchi, Junichi, Umeda, Masato, Bird, Thomas D, Sturley, Stephen L, Schon, Eric A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: European Molecular Biology Organization 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492725/
https://ncbi.nlm.nih.gov/pubmed/22892566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.202
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