α-Synuclein Is Localized to Mitochondria-Associated ER Membranes

Familial Parkinson disease is associated with mutations in α-synuclein (α-syn), a presynaptic protein that has been localized not only to the cytosol, but also to mitochondria. We report here that wild-type α-syn from cell lines, and brain tissue from humans and mice, is present not in mitochondria...

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Main Authors: Guardia-Laguarta, Cristina, Area-Gomez, Estela, Rüb, Cornelia, Liu, Yuhui, Magrané, Jordi, Becker, Dorothea, Voos, Wolfgang, Schon, Eric A., Przedborski, Serge
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866487/
https://ncbi.nlm.nih.gov/pubmed/24381286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2507-13.2014
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