Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome

Assembly of a spliceosome, catalyzing precursor–messenger RNA splicing, involves multiple RNA–protein remodeling steps, driven by eight conserved DEXD/H-box RNA helicases. The 250-kDa Brr2 enzyme, which is essential for U4/U6 di-small nuclear ribonucleoprotein disruption during spliceosome catalytic...

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Bibliografske podrobnosti
Main Authors: Santos, Karine F., Jovin, Sina Mozaffari, Weber, Gert, Pena, Vladimir, Lührmann, Reinhard, Wahl, Markus C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491510/
https://ncbi.nlm.nih.gov/pubmed/23045696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208098109
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