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Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome
Assembly of a spliceosome, catalyzing precursor–messenger RNA splicing, involves multiple RNA–protein remodeling steps, driven by eight conserved DEXD/H-box RNA helicases. The 250-kDa Brr2 enzyme, which is essential for U4/U6 di-small nuclear ribonucleoprotein disruption during spliceosome catalytic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491510/ https://ncbi.nlm.nih.gov/pubmed/23045696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208098109 |
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